H. pylori Eradication: Why Safety & Compliance Matter More Than Ever?

Successful Helicobacter pylori treatment goes beyond prescribing the right antibiotics, patient compliance is key.

A recent review (https://doi.org/10.1080/14740338.2024.2338245) emphasizes that non-compliance is the leading modifiable cause of treatment failure.

Key insights:

  • Adverse events, though mostly mild and temporary, often lead to early discontinuation.
  • Educating patients on what to expect improves adherence.
  • Simplified regimens & clear communication = better outcomes.
  • Patient reassurance: most side effects are not dangerous, and stopping treatment often causes more harm than good.

From the European Registry (@Hp-EuReg), real-world data shows:

  • Only 1.7% of patients discontinued treatment
  • Women and penicillin-allergic patients showed higher non-compliance
  • Rescue treatments had higher drop-out rates than first-line therapy
    (Source: https://doi.org/10.1002/ueg2.12569)

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